Systematic review of studies comparing the anti-caries efficacy of children’s toothpaste containing 600 ppm of fluoride or less with high fluoride toothpastes of 1000 ppm or above

Toothpastes containing 250 ppm F were not as effective in caries prevention in permanent dentition as those containing 1000 ppm F. Data comparing 500 ppm with 1000 ppm fluoride toothpastes were very limited and further research is required