In situ remineralization of white-spot enamel lesions by 500 and 1,100 ppm F dentifrices

The aim of this study was to evaluate the remineralization potential of three silica-containing NaF dentifrice systems in an intraoral model. 30 participants engaged in twice-daily brushing for 2 min with one of the following dentifrices:
500 ppm F,
500 ppm F plus functionalized β-tricalcium phosphate (fTCP),
and a clinically proven 1,100 ppm F.

The combination of fTCP and fluoride in a single-compartment, water-based dentifrice can cooperate with fluoride to produce significant remineralization. These results suggest that the combination of 500 ppm F with fTCP may provide comparable anticaries benefits relative to a 1,100 ppm F dentifrice.