Efficacy of two calcium phosphate pastes on the remineralization of artificial caries: a randomized controlled double-blind in situ study

The aim of our study was to compare the efficacy of CPP–ACPF and f TCP (calcium phosphate pastes) with that of conventional 0.1% fluoride toothpaste in remineralizing enamel artificial caries lesions in a randomized, controlled, double-blind, crossover in situ trial.

CPP–ACP is available as a professional dental product (GC Tooth Mousse; GC Corporation, Tokyo, Japan). GC Tooth Mousse containing 0.09% fluoride is available as a CPP–ACPF paste (GC Tooth Mousse Plus; GC Corporation, Tokyo, Japan).

f TCP has been shown to have remineralizing effects in both in vitro and in situ studies. f TCP has been commercially developed, and is now available as a 950 ppm fluoride toothpaste (Clinpro Tooth Crème; 3M ESPE, Saint Paul, MN, USA).



In conclusion, all three groups remineralized the enamel slab lesions, indicating model sensitivity to fluoride. Given the differences in usage amounts and treated regimens, Clinpro Tooth Crème provided similar benefits to the 0.1% fluoride toothpaste, however, no additional benefit of Tooth Mousse Plus was observed when used in conjunction with the 0.1% fluoride toothpaste.