Contemporary technologies for remineralization therapies: A review

Looking at the evidence base, it is clear that, other than
for fluoride, the strongest level of clinical evidence for
remineralization is for the casein phosphopeptide-based
Recaldent technology, with both long term large scale
clinical trials and randomized controlled clinical trials to
support its efficacy.
This is perhaps not surprising given its ontogeny, particularly its similarity to other proteins which stabilize calcium and phosphate in body
fluids.
The evidence base for other novel methods can perhaps best be summarized as “preliminary”, since at this time they are interesting from the scientific standpoint but have little in the way of laboratory, human in situ, or clinical trial data to support their use, and certainly cannot be promoted as being equal or superior to either fluoride or Recaldent. It is important for dental professionals to be aware that it takes significant time to establish the bona fides of a new technology, and that a “watching brief” is necessary in this rapidly professing area of dental science.